www.feizichem.com    Shijiazhuang FeiZi Chemical Technology Co., Ltd. 

Recently, exciting news emerged from China's scientific community—the research team led by Researcher Zhang Xiaheng from the Hangzhou Institute for Advanced Studies, University of Chinese Academy of Sciences, published a groundbreaking research achievement in the journal Nature, successfully overcoming the bottleneck in aromatic amine conversion technology that has plagued the chemical industry for 140 years. This disruptive breakthrough not only brings new possibilities to industries such as pharmaceuticals and material manufacturing but also offers companies like Feizi Chemical, which are deeply involved in the chemical sector, a glimpse of hope for industrial upgrading.

‌Core Breakthroughs of the Technological Revolution‌

‌Addressing the Pain Points of Traditional Processes‌
In traditional industrial processes, the conversion of aromatic amines requires diazonium salt intermediates, which inherently suffer from issues such as poor stability, high explosion risks, excessive copper consumption, and limited substrate applicability.

‌Pioneering a New Deaminative Functionalization Pathway‌
The research team innovatively proposed using N-nitramines as key intermediates, achieving direct conversion of aromatic carbon-nitrogen bonds into various chemical bonds—such as carbon-halogen bonds, carbon-oxygen bonds, carbon-nitrogen bonds, and carbon-carbon bonds—through nitric acid mediation, bypassing the constraints of diazonium salt processes for the first time.

‌One-Pot Method for Efficient Scalability‌
The team developed a "one-pot deaminative cross-coupling" technology that requires only the addition of common, inexpensive reagents to the reaction system to simultaneously accomplish multiple cross-couplings, enabling kilogram-scale production capacity.

‌Industry Outlook for Feizi Chemical‌
As a company consistently focused on cutting-edge chemical technologies, Feizi Chemical believes this breakthrough will deliver three major industrial benefits:

· ‌Safety Upgrade‌: Completely avoiding the explosion risks associated with traditional diazonium salt processes.

· ‌Cost Optimization‌: Significantly reducing precious metal consumption and waste treatment costs.

· ‌Application Expansion‌: Opening up new avenues for the development of pharmaceutical intermediates and specialty materials.

‌Future Application Prospects‌
This technology has already demonstrated potential in areas such as the synthesis of antitumor drugs and the modification of polymer materials. This major breakthrough, symbolizing China's independent innovation capability in the chemical industry, is redefining the future landscape of global fine chemical production.

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