CAS Number 13498-14-1

Molecular formula: Cl4O3P2

Molecular weight: 251.76

EINECS number 236-824-4

Nature:
Pyrophosphoryl chloride is a colorless liquid with a pungent odor.
It is soluble in anhydrous ether, organic solvents and benzene, and can react with water to form phosphoric acid, hydrogen chloride and phosphate esters.
Pyrophosphoryl chloride is a strongly acidic compound with strong oxidizing properties.

Purpose:

1. Organic synthesis (phosphorylation reagent)
Synthetic phosphate ester compounds:
Used for the preparation of nucleotides, phosphate ester pesticides, flame retardants, etc., such as:

Pharmaceutical intermediates (such as antiviral drugs and anti-cancer drugs).

Pesticide intermediates (such as organophosphorus insecticides and herbicides).

Activation of peptide compounds
As a condensing agent in peptide synthesis, it promotes the coupling reaction of amino acids.

2. Medical field
Synthesis of antiviral drugs (such as acyclovir, ganciclovir and other nucleoside analogues).

Precursors of anti-cancer drugs (such as certain phosphorylated antimetabolic drugs).

3. Flame retardant production
It is used for synthesizing phosphorus-containing flame retardants to improve the fire resistance performance of materials such as plastics and rubbers.

4. Additives for lithium battery electrolyte
As a synthetic precursor for lithium salts such as LiPF₆, used in the electrolyte of lithium-ion batteries.

5. Other uses
Dye intermediates

Polymer material modifiers

Security information:
Pyrophosphoryl chloride is a corrosive compound. It can cause chemical burns when in contact with skin and eyes. Direct contact should be avoided.
When operating, be careful to avoid inhaling its vapor, as it has a pungent smell and is highly toxic.
When used for phosphate ester synthesis, it should be carried out in a fume hood, with attention paid to personal protective measures and safe operation.
It should be stored in a dry, well-ventilated and sealed container, away from fire sources and flammable substances.
If you need to use it, please operate under the guidance of a professional.

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