CAS No. 300543-56-0

Molecular formula: C17H19ClN2

Molecular weight 286.8

EINECS No. 608-439-5

(-)-1-[(4-chlorophenyl) phenylmethyl] piperazine is an organic compound, commonly abbreviated as CBZ-PZ.

Nature:
-CBZ-PZ is a white crystalline solid.
It is stable at room temperature and can be dissolved in organic solvents.
-CBZ-PZ is a chiral compound and there are two enantiomers, namely the levorotatory form and the dextrorotatory form.
Chemically, CBZ-PZ is a well-known protecting group and is often used in organic synthesis.

Purpose

1. The field of medicine
(1) Central nervous system (CNS) drugs
Antipsychotic drugs
Piperazine compounds are commonly found in antipsychotic drugs (such as aripiprazole). Dextroro-4-chloro-diphenylmethylpiperazine may act as a dopamine D2 receptor or 5-HT (serotonin) receptor modulator in the research of schizophrenia or bipolar disorder.

Anti-anxiety/anti-depression
It may affect the 5-HT1A or 5-HT2C receptors and regulate emotions and behaviors.

(2) Antihistamine drugs
H1 receptor antagonists
The diphenylmethyl structure is commonly found in antihistamines (such as diphenhydramine) and may be used in the development of allergy or sedative drugs.

(3) Anti-Parkinson's disease drugs
Dopaminergic modulator
Piperazine compounds may enhance dopamine signaling and improve movement disorders.

2. Neuroscience research
Receptor binding experiment
As a radiolabeled ligand (such as ³H or ¹⁴C labeling), it is used to study the distribution and function of dopamine receptors or serotonin receptors.

Chiral drug research
The dextrorotatory configuration may have higher activity than the levorotatory form (similar to the case of dextrorotatory methylphenidate) and is used in stereoselective drug development.

3. Chemical synthesis
Chiral intermediates
It is used for the synthesis of more complex chiral drugs (such as analogues of the antidepressant vilazzolone).

Catalyst ligand
The piperazine structure can be used as an auxiliary ligand in asymmetric synthesis.

4. Potential other applications
Anti-malaria research
Some piperazine derivatives (such as piperaquine) have antimalarial activity and may be optimized as lead compounds.

Antiviral drugs
Explore its inhibitory effect on RNA viruses (such as HCV).