CAS No. 7251-52-7

Molecular formula: C13H12N2O

Molecular weight: 212.25

EINECS number 230-663-3

1. Medicine and Medicinal Chemistry
(1) Central nervous system drugs
Sedative-hypnotic/anti-anxiety drugs
The combined structure of pyridine rings and benzene rings is commonly found in GABA receptor modulators (such as certain sleeping pills or anti-anxiety drugs), which may exert their effects by influencing neurotransmitters.

Analgesic drug intermediates
Compounds with similar structures can be used to synthesize derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) or opioid analgesics.

(2) Antibacterial/antiviral drugs
Metal enzyme inhibitors
The pyridine ring can serve as a coordination site for metal ions (such as zinc and iron), potentially for the design of antibacterial or antiviral drugs (such as HIV integrase inhibitors).

(3) Anti-tumor research
Kinase inhibitor precursors
The pyridinamide structure may target protein kinases (such as EGFR, VEGFR) and be used in the development of anti-cancer drugs.

2. Organic Synthesis and Coordination Chemistry
Transition metal ligands
The nitrogen atom and amide oxygen atom of the pyridine ring can coordinate with metals such as palladium and copper, which are used to catalyze coupling reactions (such as Suzuki and Heck reactions).

Synthesis of heterocyclic compounds
As an intermediate, it participates in the synthesis of more complex heterocyclic systems (such as quinoline, imidazole-pyridine compounds).

3. Functional materials
Fluorescent probe or sensor
The phenyl-pyridine structure may have fluorescence properties and be used for the detection of metal ions or biomolecules.

Components of liquid crystal materials:
The rigid aromatic ring structure can enhance the dielectric properties of materials and is used in liquid crystal display (LCD) materials.

4. Agricultural Chemistry
Intermediate of pesticides or herbicides:
Pyridinamide compounds are used in agriculture as insecticides (such as neonicotinoid derivatives) or fungicides.